Dr. Anna Wu

Research

1. To design 'domino' strategies which enable the formation of multiple bonds in a single step, and to explore new domino reactions in palladium catalysis, which are connected by the principle of reaction initiation through nucleopalladation to access polycyclic alkaloids as bioactive agents.1.1 Palladium-catalysed enantioselective enyne cyclisations to form quaternary stereocenters via asymmetric counterion directed catalysis: Application of Dehydroabietic Acid in Palladium-Catalysed Enyne Cycloisomerisation, Na Wu*, Ruikun Li, Feihu Cui and Yingming Pan, Adv. Synth. Catal., 2017, 359(14), 2442.1.2 Pauson-Khand reactions (PKR) to form substituted cyclopentenones as found in complex natural products: Highly Stereoselective Construction of the Framework of Pentalenolactone: First Total Synthesis of (±)-Pentalenolactone A Methyl Ester, Qi Liu, Guozong Yue, Na Wu, Guang Lin, Yuanzhen Li, Chuangchuang Li, Junmin Quan, Guoxin Wang and Zhen Yang*, Angew. Chem. Int. Ed., 2012, 51, 12072. Top 10 Most Accessed Article in October, 2012.Highlighted in Chin. J. Org. Chem., January, 2013.Highlighted in Chemistry World, November, 2012.1.3 Mechanistic studies in palladium-catalysed Pauson-Khand reactions initiated by alkynoate chloropalladation rather than the conventional cyclometallation pathway; Control of Pauson-Khand reactions regioselectivity using lithium halide salts: Reverse Regioselectivity in the Pd(II)-Thiourea Catalyzed Intermolecular Pauson-Khand Reaction, Na Wu, Lujiang Deng, Lianzhu Liu, Qi Liu, Chuangchuang Li and Zhen Yang*, Chem. Asian. J., 2013, 8 (1), 65.1.4 Enyne cycloisomerisation / Diels-Alder reaction / alkoxycarbonylation / lactonisation sequences as atom economic routes to afford fused carbocyclic lactones: Application of Dehydroabietic Acid in Palladium-Catalysed Enyne Cycloisomerisation, Na Wu*, Ruikun Li, Feihu Cui and Yingming Pan, Adv. Synth. Catal., 2017, 359(14), 2442. TfOH-Catalyzed Reaction of Bispropargyl Alcohols with 1,3-Dicarbonyl Compounds, Qing-hu Teng, Shi-kun Mo, Jian-kun Pan, Na Wu,* Heng-shan Wang and Ying-ming Pan*, Synthesis, 2016, 3, 455. Highlighted in ChemInform., 2016, 47 (25), DOI: 10.1002/chin.201625089. Atom-economical Chemoselective Synthesis of Furocoumarins via Cascade Palladium Catalyzed Oxidative Alkoxylation of 4-Oxohydrocoumarins and Alkenes, Xian-chun Tan, Hai-yuan Zhao, Ying-ming Pan,* Na Wu, Heng-Shan Wang and Zhen-feng Chen*, RSC Adv., 2015, 5, 4972.Highlighted in ChemInform., 2015, 46 (24), DOI: 10.1002/chin.201524163A Model Study for the Concise Construction of the Oxapentacyclic Core of Cortistatins through Intramolecular Diels-Alder and Oxidative Dearomatization-Cyclization Reactions, Lianzhu Liu, Yingxiang Gao, Chao Che, Na Wu, David ZhigangWang, ChuangChuang Li and Zhen Yang*, Chem. Commun., 2009, 6, 662. Highlighted in ChemInform, 2009, 40, DOI: 10.1002/chin.200925181. Unexpected Regioselectivity in the Synthesis of Pyranonaphthoquinone via the Diels-Alder Reaction, Yi Cui, Hao Jiang, Zhengtao Li, Na Wu, Zhen Yang* and Junmin Quan, Org. Lett., 2009, 11, 4628. Diversity-Oriented Synthesis of Fused Pyran γ-Lactones via an Efficient Pd-Thiourea-Catalyzed Alkoxycarbonylative Annulation, Zhengtao Li, Yingxiang Gao, Zhaodong Jiao, Na Wu, David Zhigang Wang and Zhen Yang*, Org. Lett., 2008, 10, 5163. Highlighted by Mark Lautens, David A. Candito. Synfacts 2009, 2, 0188. 1.5 Electron-reverse reductive Heck cyclisation (Hydroarylation) of en-ynamide to indoles / hydride migration: Palladium-Catalysed Ligand-Free Reductive Heck Cycloisomerisation of 1,6-En-α-chloro-enamides, Yangyang Hou, Jing Ma, Hongyi Yang, Andy Whiting, Edward A. Anderson and Na Wu*, Chem. Commun., 2019, 55, 3733.1.6 Wagner-Meerwein-type rearrangements of en-ynones to access polycyclic pyrones, model synthesis of nodulisporic acid and taiwaniaquinol: Palladium(II)-Catalyzed Tandem Cyclisation of Electron-Deficient Aromatic Enynes, Na Wu, Antonios Messinis, Andrei S. Batsanov, Zhen Yang, Andrew Whiting and Todd. B. Marder*, Chem. Commun., 2012, 48 (80), 9986. Highlighted in ChemInform., 2013, 44, DOI: 10.1002/chin.201303035. Highlighted by Synfacts 2012, 8 (12), 1295.An Irreversible Phase Transition in 1-n-butylindeno[2,1-c]pyran-3,9-dione, Andrei S. Batsanov*, Judith A. K. Howard, Na Wu, Zhen Yang and Todd B. Marder, Acta Cryst., 2012, C68, o413.1.7 Synthesis of β-enaminoketoesters via “masked” 1,3-aza-dipoles cascade rearrangements: One-Pot Stepwise Approach to β-Enaminoketoesters through “Masked” 1,3-Aza-Dipoles, Zhi-ming Yan, Na Wu*, Dong Liang, Heng-shan Wang and Ying-ming Pan*, Org. Lett., 2014, 16, 4048. Highlighted in ChemInform., 2015, 46 (4), DOI: 10.1002/chin.2015040541.8 Developing new chiral dienes from extracts of plants for use in rhodium catalysis:Nordehydroabietyl Amide-Containing Chiral Diene for Rhodium-Catalysed Asymmetric Arylation to Nitroolefins, Ruikun Li, Zhongqing Wen and Na Wu*, Org. Biol. Chem., 2016, 14, 11080.1.9 Mechanistic study of racemic and asymmetric nucleophilic addition of trichloromethanide to Michael acceptors: 1,4-Addition of TMSCCl3 to Nitroalkenes: Efficient Reaction Conditions and Mechanistic Understanding, Na Wu, Benoit Wahl, Simon Woodward* and William Lewis, Chem. Eur. J., 2014, 20, 7718. Highlighted in ChemInform., 2014, 45 (51), DOI: 10.1002/chin.2014510262. To synthesize useful building blocks ynamides and ynamines, as well as their utilisation into delivering light-harvesting and fluorescent materials.2.1 To develop an easy-to-handle, ready-to-scale-up method that would be attractive in industry to access diversified ynamides and ynamines, via copper-free Sonogashira coupling reaction in water. The currently environmentally-friendly simple route allows for large scale preparation of ynamides, and further, providing a practical perspective on the de novo synthesis of complex natural product-based ynamides. Synthesis of Sulfonamide-Based Ynamides and Ynamines in Water, Lei Zhao, Hongyi Yang, Ruikun Li, Ye Tao, Xiao-Feng Guo, Edward A. Anderson, Andy Whiting and Na Wu*, , 2021, 86(2), 1938.Highlighted by Organic Chemistry Portal as useful chemistry: https://www.organic-chemistry.org/abstracts/lit7/743.shtmHighlighted by Chin. J. Chem. 2023, 41, 1099-1118. 2.2 The Chemistry of Ynamide and Its Application in Organic Synthesis, Siyu Ye and Na Wu*, eds: A. Rahma, Advances in Organic Synthesis, 13th ed. Bentham: the Netherlands, 2020, 13(2), 52-170.2.3 Functionalisation of ynamides / ynamines with iodonium salts to afford acyloxyl amide. Metal-Free Oxyacetoxylation of Arylynamines and Ynamides to Construct α-Acetoxyl Amides, Rong Long, Shaoling Huang, Han-Kui Wu, Naila Iqbal and Na Wu*, Eur. J. Org. Chem., 2023, DOI: 10.1002/ejoc.202300393.2.4 Synthesis of Orthogonal Push-Pull Chromophores via Click Reaction of Arylynamines, Shuangping Huang, Jing Ma, Yikun Yi, Mingtao Li, Ping Cai and Na Wu*, Org. Biomol. Chem., 2022, 20, 4081. Key words: palladium, copper catalysis, dipolar cycloaddition, metal-free enyne cyclisation. opportunities to join us: Schlumberger faculty for the future:https://www.fftf.slb.com/Commonwealth PhD scholarship, master scholarship:https://lnkd.in/gcxWdSCNChinese Scholarship Council visiting scholarship:https://lnkd.in/gyKcAcZ4 Nigerian Tertiary Fund Trust: https://tetfund.gov.ng/index.php/guideline-10/