Dr. Goreti Ribeiro Morais
Information about Dr. Goreti Ribeiro Morais at the University of Bradford.
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Biography
Goreti Ribeiro Morais obtained her degree in Pharmacy from the University of Coimbra and received her PhD in Pharmaceutical Chemistry from the University of Lisbon (Portugal)/University of Kyushu (Japan). Then she conducted a three-year postdoctoral stay at the Institute of Cancer Therapeutics (ICT), University of Bradford followed by a research scientist position at the Radiopharmaceutical Sciences Group/Technical University of Lisbon. In late 2014 she moved back at the ICT as senior PDRA to integrate the Yorkshire Cancer Research Programme grant. She made significant contributions towards three main medicinal chemistry projects (polysialyltransferase inhibitors, Cytochromes P450-activated prodrugs, and MMP-activated prodrugs) of the ICT and was crucial for the strengthening of the collaborations with Stanford University, Incanthera and Ellipses Pharma. Since 2019 she has played a key role in the successful Incanthera-funded doctoral Training centre (DTC-ICT). In addition to the training and mentoring of the medicinal chemistry postgraduate students of the ICT, she acted as formal co-supervisor of three PhD students (each successfully completed, and have secured excellent jobs in industry (2) and academia (1)) and two international undergraduate students. Currently she is co-supervisor of one PhD student and one MSc student. She has authored 50 peer-reviewed journal articles, 7 of which as corresponding author, 1 book chapter, 1 patent and 17 published abstracts in international conferences. Moreover, she has teaching responsibilities in three Master courses and holds a PAT role for MPharm students.
Professional activities
Information about education, employment and areas of particular interest for Dr. Goreti Ribeiro Morais is as follows:
Employment
- University of Bradford - Senior Post-Doctoral Fellow in the year 2014 (specified as 06/10/2014)
Education
- University of Coimbra, Portugal - PGDipPharm
- University of Lisbon, Portugal - PhD Thesis
Publications
There are 40 publications involving or that are attributed to Dr. Goreti Ribeiro Morais. They are listed as:
- chapter in book (1)
- peer reviewed journal (39)
Chapter in Book
| Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Organometallic Chemistry of Rhenium and Technetium Fueled by Biomedical Applications | 2013 | ISBN: 9781118510148 | 10.1002/9781118742952.ch44 |
Peer Reviewed Journal
| Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Biophysical Characterization and Antineoplastic Activity of New Bis(thiosemicarbazonato) Cu(II) Complexes | 2017 | Journal of Inorganic Biochemistry | 10.1016/j.jinorgbio.2016.11.026 | ||||||||
| Acid catalysed reaction of indanones, tetralones and benzosuberone with neopentyl glycol and other alkanediols under forced conditions | 2010 | Journal of Chemical Research-S | 10.3184/030823410X12753214605445 | ||||||||
| Acid catalysed reaction of estrones with neopentyl glycol under forced conditions | 2010 | Journal of Chemical Research-S | 10.3184/030823410X12678785299942 | ||||||||
| Steroid receptor ligands for breast cancer targeting: an insight into their potential role as PET imaging agents | 2013 | Current Medicinal Chemistry | 10.2174/092986713804806658 | ||||||||
| Application of HOF·CH3CN to the synthesis of glycosyl sulphones | 2008 | Tetrahedron | 10.1016/j.tet.2008.05.033 | ||||||||
| Novel strategies for the synthesis of unsymmetrical glycosyl disulfides | 2016 | Organic and Biomolecular Chemistry | doi.org/10.1039/C6OB00230G | ||||||||
| Efficient one-pot synthesis of glycosyl disulphides | 2007 | Tetrahedron Letters | 10.1016/j.tetlet.2007.08.106 | ||||||||
| Radioiodinated ligands for the estrogen receptor: effect of different 7-cyanoalkyl chains on the binding affinity of novel iodovinyl-6-dehydroestradiols | 2009 | Applied Radiation and Isotopes | 10.1016/j.apradiso.2008.10.005 | ||||||||
| Selective synthesis of Neu5Ac2en and its oxazoline derivative using BF3.Et2O | 2009 | Tetrahedron Letters | 10.1016/j.tetlet.2009.01.117 | ||||||||
| A synthetic overview of radiolabeled compounds for β-amyloid targeting | 2012 | European Journal of Organic Chemistry | 10.1002/ejoc.201101449 | ||||||||
| Organometallic complexes for SPECT Imaging and/or Radionuclide Therapy | 2012 | Organometallics | 10.1021/om300501d | ||||||||
| Carbohydrate-based molecules suitable for nuclear molecular imaging | 2013 | European Journal of Organic Chemistry | 10.1002/ejoc.201201457 | ||||||||
| Progesterona receptor targeting with radiolabelled steroids: an approach in predicting Breast Cancer Response to Therapy | 2013 | Journal of Steroid Biochemistry and Molecular Biology | 10.1016/j.jsbmb.2013.04.003 | ||||||||
| Radiosynthesis and in vivo Evaluation of a 18F-Labelled Styryl-Benzoxazole Derivative for beta-Amyloid Targeting | 2013 | Applied Radiation and Isotopes | 10.1016/j.apradiso.2013.07.003 | ||||||||
| The Tumor-Targeted Prodrug ICT2588 Demonstrates Therapeutic Activity Against Solid Tumors and Reduced Potential For Cardiovascular Toxicity | 2014 | Molecular Pharmaceutics | 10.1021/mp400760b | ||||||||
| Isostructural Re(I)/99mTc(I) Tricarbonyl Complexes Functionalized with Benzothiazole Derivatives for Cancer Theranostic | 2015 | Organic and Biomolecular Chemistry | 10.1039/c5ob00124b | ||||||||
| Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment | 2016 | Scientific Reports | 10.1038/srep33026 | ||||||||
| Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutics Agents” | 2017 | Journal of Heterocyclic Chemistry | 10.1002/jhet.2575 | ||||||||
| Unravelling the antitumoral potential of novel bis(thiosemicarbazonato) Zn(II) complexes: structural and cellular studies | 2019 | Journal of Biological Inorganic Chemistry | 10.1007/s00775-018-1629-6 | ||||||||
| An efficient assay for identification and quantitative evaluation of potential polysialyltransferase inhibitors | 2020 | The Analyst | doi.org/10.1039/D0AN00721H | ||||||||
| How can the potential of the duocarmycins be unlocked for cancer therapy? | 2021 | Drug Discovery Today | 10.1016/j.drudis.2020.11.020 | ||||||||
| Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds | 2021 | Bioorganic and Medicinal Chemistry | 10.1016/j.bmc.2021.116167 | ||||||||
| Cytochrome P450 isoforms 1A1, 1B1 AND 2W1 as targets for therapeutic intervention in head and neck cancer | 2021 | Scientific Reports | 10.1038/s41598-021-98217-z | ||||||||
| Targeted delivery of a colchicine analogue provides synergy with ATR inhibition in cancer cells | 2022 | Biochemical Pharmacology | 10.1016/j.bcp.2022.115095 | ||||||||
| Dess–Martin periodinane-mediated oxidation of the primary alcohol of cytidine into a carboxylic acid | 2024 | Organic and Biomolecular Chemistry | 22 | Serre, A.R.E;Jha, V.;Rivault, A.;Eriksson, L.A.;Ribeiro Morais, G.;Falconer, R.A. | Royal Society of Chemistry | 10.1039/d4ob00240g | |||||
| Simple amidation of non-protected phenol containing 2-alkenoic acids | 2005 | Journal of Chemical Research-S | 10.3184/030823405775146889 | ||||||||
| Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes | 2011 | Bioorganic and Medicinal Chemistry | 10.1016/j.bmc.2011.09.065 | ||||||||
| An optimized method for the synthesis of amino functionalized phosphatidylcholine | 2012 | Tetrahedron Letters | 10.1016/j.tetlet.2011.11.100 | ||||||||
| Probing cytochrome P450 bioactivation and fluorescent properties with morpholinyl-tethered anthraquinones | 2018 | Bioorganic and Medicinal Chemistry Letters | 10.1016/j.bmcl.2018.03.040 | ||||||||
| Theranostic nanoparticles enhance the response of glioblastomas to radiation | 2019 | Nanotheranostics | DOI: 10.7150/ntno.35342 | ||||||||
| Glycosyl disulfides: importance, synthesis and application to chemical and biological systems | 2021 | Organic and Biomolecular Chemistry | doi.org/10.1039/D0OB02079F | ||||||||
| Chemoselective Solution- and Solid-Phase Synthesis of Disulfide-Linked Glycopeptides | 2022 | Journal of Organic Chemistry | doi.org/10.1021/acs.joc.2c01651 | ||||||||
| An assay for quantitative analysis of polysialic acid expression in cancer cells | 2021 | Carbohydrate Polymers | 10.1016/j.carbpol.2021.117741 | ||||||||
| Pharmacological inhibition of polysialyltransferase ST8SiaII modulates tumour cell migration | 2013 | PLoS ONE | 10.1371/journal.pone.0073366 | ||||||||
| A Novel Theranostic Strategy for MMP-14–Expressing Glioblastomas Impacts Survival | 2017 | Molecular Cancer Therapeutics | 10.1158/1535-7163.MCT-17-0022 | ||||||||
| Azodicarboxylate-Mediated Peptide Cyclisation: Application to Disulfide Bond Formation in Solution and Solid Phase | 2023 | European Journal of Organic Chemistry | doi.org/10.1002/ejoc.202300789 | ||||||||
| Identification of an acetyl disulfide derivative in the synthesis of thiosialosides | 2010 | Carbohydrate Research | 10.1016/j.carres.2009.10.017 | ||||||||
| Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents | 2022 | Drug Metabolism and Disposition | doi.org/10.1124/dmd.121.000642 | ||||||||
| A facile preparation of thio-trehalose analogues – 1,1-thiodissacharides | 2009 | Carbohydrate Research | 10.1016/j.carres.2009.03.017 |