Professor Colin Wright,Professor of Pharmacognosy
Information about Professor Colin Wright at the University of Bradford.
- School of Pharmacy & Medical Sciences
(Faculty of Life Sciences) - Email:
- c.w.wright@bradford.ac.uk
- Telephone:
- +44 1274 234739
Biography
I started my career as a hospital pharmacist and became interested in tropical diseases as well as traditional medicine while working as a pharmacist in India (1980-1982). This led to my long-term interest in pharmacognosy and research in traditional medicines used in the treatment of infectious diseases and cancer. I have taught pharmacognosy for more than 20 years with the principal aims of highlighting the importance of natural products in medicine & drug discovery as well as revealing their fascinating chemistry and pharmacological effects. When I started at Bradford School of Pharmacy in 1994, the teaching of Pharmacognosy was fairly traditional including analytical microscopy. Working with Dr Peter Linley, I developed this subject area to provide modules that were more relevant to modern pharmacy practice by illustrating through lectures and lab workshops why a knowledge of herbal medicines and natural products is necessary for the practising pharmacist. Similarly, I developed a module on natural products for the (former) M.Sc in Pharmaceutical Services and Medicines Control. Although pharmacognosy as a subject is no longer in the new pharmacy curriculum, I have been able to include some content e.g. in unit FS2 which includes the origins of drugs and eco-pharmacy and a number of applications exercises present problems involving herbal medicines/natural products. Also, herbal medicines is a topic for student selected components and I offer natural product-related laboratory research projects. My research has focussed mainly on the investigation of traditional medicines used for the treatment of malaria with the aim of identifying lead antimalarial compounds. In collaboration with Bradfordâs Institute for Cancer Research I have also investigated plants including marine algae (seaweeds) for their potential to yield anticancer compounds. I also have an interest in anti-TB natural products. My main research achievement has been the study of cryptolepine for which I received funding from WHO and is described in more detail below. I have successfully supervised 20 PhD students whose work, together with the help of many collaborators has resulted in the publication of 98 research papers and more than 100 conference contributions. In addition, I am regularly invited to present my research at conferences and seminars. I actively participate in two of the research groups in the School of Pharmacy especially in the Medicines Development and Pharmaceutical Science group in which I line manage 7 academic staff and have a role in facilitating the groupâs research ambitions and strategy.
Publications
There are 94 publications involving or that are attributed to Professor Colin Wright.
Peer Reviewed Journal
Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
---|---|---|---|---|---|---|---|---|---|---|---|
The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites. | 2001 | Lisgarten, J.N.; Coll, M.; Portugal, J.; Wright, Colin W.; Aymami, J. | |||||||||
Antiprotozoal activities of Centipeda minima | 1994 | Phytotherapy Research | 8 | 436 - 438 | Yu H.;Wright C.;Cai Y.;Yang S.;Phillipson J.;Kirby G.;Warhurst D. | 0951-418X | 10.1002/ptr.2650080713 | ||||
Alkaloids from Narcissus cantabricus | 1995 | Phytochemistry | 40 | 1549 - 1551 | Bastida J.;Contreras J.;Codina C.;Wright C.;David Phillipson J. | 0031-9422 | 10.1016/0031-9422(95)00448-G | ||||
Toward the chemical ecology of medicinal plant use in chimpanzees: The case of Vernonia amygdalina, a plant used by wild chimpanzees possibly for parasite-related diseases | 1994 | Journal of Chemical Ecology | 20 | 541 - 553 | Ohigashi H.;Huffman M.;Izutsu D.;Koshimizu K.;Kawanaka M.;Sugiyama H.;Kirby G.;Warhurst D.;Allen D.;Wright C.;David Phillipson J.;Timon-David P.;Delmas F.;Elias R.;Balansard G. | 0098-0331 | 10.1007/BF02059596 | ||||
Selective antiprotozoal activity of some Strychnos alkaloids | 1994 | Phytotherapy Research | 8 | 149 - 152 | Wright C.;Allen D.;Cai Y.;Chen Z.;Phillipson J.;Kirby G.;Warhurst D.;Tits M.;Angenot L. | 0951-418X | 10.1002/ptr.2650080306 | ||||
In vitro antiplasmodial, antiamoebic, and cytotoxic activities of a series of bisbenzylisoquinoline alkaloids | 1994 | Antimicrobial Agents and Chemotherapy | 38 | 96 - 103 | Marshall S.;Russell P.;Wright C.;Anderson M.;Phillipson J.;Kirby G.;Warhurst D.;Schiff P. | 0066-4804 | 10.1128/AAC.38.1.96 | ||||
Alkaloids from Cephaelis dichroa | 1993 | Phytochemistry | 33 | 1117 - 1119 | Solis P.;Wright C.;Gupta M.;Phillipson J. | 0031-9422 | 10.1016/0031-9422(93)85033-N | ||||
Alstonia species: are they effective in malaria treatment? | 1993 | Journal of Ethnopharmacology | 40 | 41 - 45 | Wright C.;Allen D.;Phillipson J.;Kirby G.;Warhurst D.;Massiot G.;Le Men-Olivier L. | 0378-8741 | 10.1016/0378-8741(93)90087-L | ||||
A microwell cytotoxicity assay using Artemia salina (brine shrimp) | 1993 | Planta Medica | 59 | 250 - 252 | Solis P.;Wright C.;Anderson M.;Gupta M.;Phillipson J. | 0032-0943 | |||||
Quassinoids Exhibit Greater Selectivity Against Plasmodium Falciparum Than Against Entamoeba Histolytica, Giardia Intestinalis Or Toxoplasma Gondii In Vitro | 1993 | Journal of Eukaryotic Microbiology | 40 | 244 - 246 | WRIGHT C.;ANDERSON M.;ALLEN D.;PHILLIPSON J.;KIRBY G.;WARHURST D.;CHANG H. | 1066-5234 | 10.1111/j.1550-7408.1993.tb04910.x | ||||
In vitro antimalarial and cytotoxic activities of semisynthetic derivatives of brusatol | 1993 | European Journal of Medicinal Chemistry | 28 | 265 - 269 | Allen D.;Toth I.;Wright C.;Kirby G.;Warhurst D.;Phillipson J. | 0223-5234 | 10.1016/0223-5234(93)90143-3 | ||||
Determination of anti-giardial activity in vitro by means of soluble formazan production | 1992 | Transactions of the Royal Society of Tropical Medicine and Hygiene | 86 | 517 - 519 | Wright C.;Melwani S.;David Phillipson J.;Warhurst D. | 0035-9203 | 10.1016/0035-9203(92)90093-R | ||||
Parasitological and microbiological evaluation of Mixe Indian medicinal plants (Mexico). | 1992 | Journal of Ethnopharmacology | 36 | Heinrich M;Kuhnt M;Wright CW;Rimpler H;Phillipson JD;Schandelmaier A;Warhurst DC; | 0378-8741 | ||||||
In vitro antiamoebic and antiplasmodial activities of alkaloids isolated from Alstonia angustifolia roots | 1992 | Phytotherapy Research | 6 | 121 - 124 | Wright C.;Allen D.;Cai Y.;Phillipson J.;Said I.;Kirby G.;Warhurst D. | 0951-418X | 10.1002/ptr.2650060303 | ||||
A new alkaloid from the roots of alstonia angustifolia | 1992 | Journal of Natural Products | 55 | 1323 - 1324 | Said I.;Din L.;Yusoff N.;Wright C.;Cai Y.;Phillipson J. | 0163-3864 | 10.1021/np50087a025 | ||||
Molecular modelling of usambarensine, tubulosine and emetine, three cytotoxic amoebicide alkaloids | 1991 | Journal de Pharmacie de Belgique | 46 | 85 - 92 | Quetin-Leclercq J.;Dupont L.;Wright C.;Phillipson J.;Warhurst D.;Angenot L. | 0047-2166 | |||||
Can ethnopharmacology contribute to the development of antimalarial agents? | 1991 | Journal of Ethnopharmacology | 32 | 155 - 165 | David Phillipson J.;Wright C. | 0378-8741 | 10.1016/0378-8741(91)90113-R | ||||
Antiamoebic and antiplasmodial activities of alkaloids isolated from Strychnos usambarensis. | 1991 | Planta Medica | 57 | Wright CW;Bray DH;O'Neill MJ;Warhurst DC;Phillipson JD;Quetin-Leclercq J;Angenot L; | 0032-0943 | 10.1055/s-2006-960112 | |||||
Plants as sources of antimalarial drugs, part 6: Activities of Simarouba amara fruits | 1988 | Journal of Ethnopharmacology | 22 | 183 - 190 | O'Neill M.;Bray D.;Boardman P.;Wright C.;David Phillipson J.;Warhurst D.;Gupta M.;Correya M.;Solis P. | 0378-8741 | 10.1016/0378-8741(88)90126-2 | ||||
Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of quassinoids. | 1988 | Antimicrobial Agents and Chemotherapy | 32 | Wright CW;O'Neill MJ;Phillipson JD;Warhurst DC; | 0066-4804 | ||||||
Pharmacy Education: Understanding drug abuse | 1993 | Pharmaceutical Journal | 250 | Wright, C.W. | |||||||
A cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations used in Ghana | 2008 | Natural product communications | Bayor, M.T.;Ayim, J.S.K.;Marston, G.;Phillips, R.M.;Shnyder, S.D.;Wheelhouse, R.T.;Wright, C.W.; | ||||||||
In-vitro cytotoxicity and thermodenaturation studies for cryptolepine and analogues | 2000 | Journal of Pharmacy and Pharmacology | 52 | 109 | Gokcek Y.;Pollet P.;Wright C.;Brown J. | 0022-3573 | |||||
In-vitro antimycobacterial screening of some plant species used in traditional medicine for the treatment of tuberculosis | 2000 | Journal of Pharmacy and Pharmacology | 52 | 310 | Newton S.;Lau C.;Wright C. | 0022-3573 | |||||
Antimalarial ethnobotany: In vitro antiplasmodial activity of seven plants identified in the Nigerian Middle Belt | 2004 | Pharmaceutical Biology | 42 | 588 - 591 | Ajaiyeoba E.;Ashidi J.;Abiodun O.;Okpako L.;Ogbole O.;Akinboye D.;Falade C.;Bolaji O.;Gbotosho G.;Falade M.;Itiola O.;Houghton P.;Wright C.;Oduola A. | 1388-0209 | 10.1080/13880200490902455 | ||||
Antiplasmodial principles from Cassia nigricans | 2004 | Pharmaceutical Biology | 42 | 626 - 628 | Obodozie O.;Okpako L.;Tarfa F.;Orisadipe A.;Okogun J.;Inyang U.;Ajaiyeoba E.;Wright C. | 1388-0209 | 10.1080/13880200490902545 | ||||
Screening indian plant species for antiplasmodial properties - Ethnopharmacological compared with random selection | 2012 | Phytotherapy Research | 26 | 1793 - 1799 | Kantamreddi V.;Wright C. | 0951-418X | 10.1002/ptr.4651 | ||||
In vitro anti-plasmodial and cytotoxic activities of plants used as antimalarial agents in the southwest Nigerian ethnomedicine | 2005 | Journal of Natural Remedies | 5 | 1 - 6 | Ajaiyeoba E.;Bolaji O.;Akinboye D.;Falade C.;Gbotosho G.;Ashidi J.;Okpako L.;Oduola O.;Falade M.;Itiola O.;Houghton P.;Wright C.;Ogundahunsi O.;Oduola A. | 0972-5547 | |||||
Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: In vivo antimalarial activity and x-ray crystal structure of normelicopicine | 2002 | Journal of Natural Products | 65 | 956 - 959 | Muriithi M.;Abraham W.;Addae-Kyereme J.;Scowen I.;Croft S.;Gitu P.;Kendrick H.;Njagi E.;Wright C. | 0163-3864 | 10.1021/np0106182 | ||||
Antiplasmodial and antiamoebic activities of medicinal plants from Sierra Leone | 2000 | Phytotherapy Research | 14 | 356 - 358 | Marshall S.;Russell P.;Phillipson J.;Kirby G.;Warhurst D.;Wright C. | 0951-418X | 10.1002/1099-1573(200008)14:5<356::AID-PTR636>3.0.CO;2-Z | ||||
Huprines as a new family of dual acting trypanocidal-antiplasmodial agents | 2011 | Bioorganic and Medicinal Chemistry | 19 | 1702 - 1707 | Defaux J.;Sala M.;Formosa X.;Galdeano C.;Taylor M.;Alobaid W.;Kelly J.;Wright C.;Camps P.;Muñoz-Torrero D. | 0968-0896 | 10.1016/j.bmc.2011.01.028 | ||||
Evaluation of Some Egyptian Plant Species for in vitro Antimycobacterial and Cytotoxic Activities | 2003 | Pharmaceutical Biology | 41 | 463 - 465 | Abou El Seoud K.;Bibby M.;Shoeib N.;Wright C. | 1388-0209 | 10.1076/phbi.41.6.463.17831 | ||||
Correlation of hyperforin content of Hypericum perforatum (St John's Wort) extracts with their effects on alcohol drinking in C57BL/6J mice: A preliminary study | 2003 | Journal of Psychopharmacology | 17 | 403 - 408 | Wright C.;Gott M.;Grayson B.;Hanna M.;Smith A.;Sunter A.;Neill J. | 0269-8811 | 10.1177/0269881103174018 | ||||
Pterocarpans phaseollin and neorautenol isolated from Erythrina addisoniae induce apoptotic cell death accompanied by inhibition of ERK phosphorylation | 2007 | Toxicology | 242 | 71 - 79 | Wätjen W.;Kulawik A.;Suckow-Schnitker A.;Chovolou Y.;Rohrig R.;Ruhl S.;Kampkötter A.;Addae-Kyereme J.;Wright C.;Passreiter C. | 0300-483X | 10.1016/j.tox.2007.09.010 | ||||
Low temperature X-ray crystallographic structure of the antiplasmodial compound 5-N-hydroxyethanequindoline hydrochloride 0.5CH |
2011 | Journal of Chemical Crystallography | 41 | 1757 - 1762 | Hampson H.;Ho C.;Palmer R.;Potter B.;Helliwell M.;Wright C. | 1074-1542 | 10.1007/s10870-011-0169-5 | ||||
Structure of the tetraphenyl borate complex of the indoloquinoline alkaloid cryptolepine | 1999 | Journal of Chemical Crystallography | 29 | 449 - 455 | Wright C.;Philpson J.;Lisgarten J.;Palmer R. | 1074-1542 | 10.1023/A:1009519211938 | ||||
Antiplasmodial activities of some Ghanaian plants traditionally used for fever/malaria treatment and of some alkaloids isolated from Pleiocarpa mutica; in vivo antimalarial activity of pleiocarpine | 2001 | Journal of Ethnopharmacology | 76 | 99 - 103 | Addae-Kyereme J.;Croft S.;Kendrick H.;Wright C. | 0378-8741 | 10.1016/S0378-8741(01)00212-4 | ||||
Sesquiterpene lactones from Neurolaena oaxacana | 1999 | Journal of Natural Products | 62 | 1093 - 1095 | Passreiter C.;Sandoval-Ramirez J.;Wright C. | 0163-3864 | 10.1021/np990038t | ||||
Seasonal variation in bromophenol content of Polysiphonia lanosa | 2006 | Natural product communications | 1 | 47 - 49 | Shoeib N.;Bibby M.;Blunden G.;Linley P.;Swaine D.;Wright C. | 1934-578X | |||||
The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis | 2002 | Journal of Ethnopharmacology | 79 | 57 - 67 | Newton S.;Lau C.;Gurcha S.;Besra G.;Wright C. | 0378-8741 | 10.1016/S0378-8741(01)00350-6 | ||||
Synthesis of cryptolepine analogues as potential bioreducible anticancer agents | 2007 | Bioorganic and Medicinal Chemistry | 15 | 6353 - 6360 | Seville S.;Phillips R.;Shnyder S.;Wright C. | 0968-0896 | 10.1016/j.bmc.2007.06.062 | ||||
In-vitro antiplasmodial and cytotoxic activities of some British species of marine algae | 2000 | Journal of Pharmacy and Pharmacology | 52 | 311 | Shoeib N.;Bibby M.;Cooper P.;Blunden G.;Wright C. | 0022-3573 | |||||
Synthetic cryptolepine inhibits DNA binding of NF-κB | 2007 | Bioorganic and Medicinal Chemistry | 15 | 43 - 49 | Olajide O.;Heiss E.;Schachner D.;Wright C.;Vollmar A.;Dirsch V. | 0968-0896 | 10.1016/j.bmc.2006.10.018 | ||||
The antimalarial and cytotoxic drug cryptolepine intercalates into dna at cytosine-cytosine sites | 2002 | Nature Structural Biology | 9 | 57 - 60 | Lisgarten J.;Coll M.;Portugal J.;Wright C.;Aymami J. | 1072-8368 | 10.1038/nsb729 | ||||
Cryptolepine hydrochloride: A potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta | 2003 | Phytotherapy Research | 17 | 434 - 436 | Gibbons S.;Fallah F.;Wright C. | 0951-418X | 10.1002/ptr.1284 | ||||
Enhancement of the Antiplasmodial Activity of Quassin by Transformation into a γ-Lactone | 2003 | Journal of Natural Products | 66 | 1486 - 1489 | Lang'at-Thoruwa C.;Kirby G.;Phillipson J.;Warhurst D.;Watt R.;Wright C. | 0163-3864 | |||||
Synthesis and antiplasmodial activities of some halogenated cryptolepine derivatives | 2000 | Journal of Pharmacy and Pharmacology | 52 | 296 | Wright C.;Addae-Kyereme J.;Brown J.;Cox M.;Gokcek Y.;Pollet P. | 0022-3573 | |||||
Synthesis of novel halogenated cryptolepine analogues | 2006 | Journal of Heterocyclic Chemistry | 43 | 171 - 175 | Gouni S.;Carrington S.;Wright C. | 0022-152X | 10.1002/jhet.5570430126 | ||||
In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids | 2000 | Journal of Natural Products | 63 | 1638 - 1640 | Wright C.;Marshall S.;Russell P.;Anderson M.;Phillipson J.;Kirby G.;Warhurst D.;Schiff J. | 0163-3864 | 10.1021/np000144r | ||||
Recent developments in naturally derived antimalarials: Cryptolepine analogues | 2007 | Journal of Pharmacy and Pharmacology | 59 | 899 - 904 | Wright C. | 0022-3573 | 10.1211/jpp.59.6.0017 | ||||
Genomewide expression profiling of cryptolepine-induced toxicity in Saccharomyces cerevisiae | 2008 | Antimicrobial Agents and Chemotherapy | 52 | 3844 - 3850 | Rojas M.;Wright C.;Piña B.;Portugal J. | 0066-4804 | 10.1128/AAC.00532-08 | ||||
In-vitro cytotoxic activities of the major bromophenols of the red alga Polysiphonia lanosa and some novel synthetic isomers | 2004 | Journal of Natural Products | 67 | 1445 - 1449 | Shoeib N.;Bibby M.;Blunden G.;Linley P.;Swaine D.;Wheelhouse R.;Wright C. | 0163-3864 | 10.1021/np0305268 | ||||
Phytochemistry and preliminary biological evaluation of Cyathostemma argenteum, a Malaysian plant used traditionally for the treatment of breast cancer | 2004 | Phytotherapy Research | 18 | 507 - 510 | Khamis S.;Bibby M.;Brown J.;Cooper P.;Scowen I.;Wright C. | 0951-418X | 10.1002/ptr.1318 | ||||
Investigation of Indian Diospyros species for antiplasmodial properties | 2008 | Evidence-based Complementary and Alternative Medicine | 5 | 187 - 190 | Kantamreddi V.;Wright C. | 1741-427X | 10.1093/ecam/nem019 | ||||
Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats | 2017 | Forkuo, A.D.; Ansah, C.; Pearson, D.; Gertsch, W.; Cirello, A.; Amaral, A.; Spear, J.; Wright, Colin W.; Rynn, C. | |||||||||
In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine | 2017 | Forkuo, A.D.; Ansah, C.; Mensah, K.B.; Annan, K.; Gyan, B.; Theron, A.; Mancama, D.; Wright, Colin W. | |||||||||
Identification of compounds with cytotoxic activity from the leaf of the Nigerian medicinal plant, Anacardium occidentale L. (Anacardiaceae) | 2017 | Taiwo, Bamigboye J.; Fatokun, Amos A.; Olubiyi, O.O.; Bamigboye-Taiwo, O.T.; van Heerden, F.R.; Wright, Colin W. | |||||||||
Synthesis and biological evaluation of N-cyanoalkyl-, Naminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents | 2016 | Sola, I.; Artigas, A.; Taylor, M.C.; Perez-Areales, F.J.; Viayna, E.; Clos, M.V.; Perez, B.; Wright, Colin W.; Kelly, J.M.; Muñoz-Torrero, D. | |||||||||
Traditional remedies: an ally in the fight against infectious diseases? | 2012 | Wright, Colin W. | |||||||||
Recent developments in research on terrestrial plants used for the treatment of malaria. | 2010 | Wright, Colin W. | |||||||||
Antileishmanial activity of cryptolepine analogues and apoptotic effects of 2,7-dibromocryptolepine against Leishmania donovani promastigotes. | 2012 | Hazra, S.; Ghosh, S.; Debnath, S.; Seville, Scott; Prajapati, V.K.; Wright, Colin W.; Sundar, S.; Hazra, B. | |||||||||
Metabolism of cryptolepine and 2-fluorocryptolepine by aldehyde oxidase | 2012 | Stell, J. Godfrey P.; Wheelhouse, Richard T.; Wright, Colin W. | |||||||||
Complete NMR assignments of tubulosine | 2012 | Kantamreddi, Venkata Siva Satya Narayana; Wright, Colin W. | |||||||||
Effects of the antimalarial compound cryptolepine and its analogues in human lymphocytes and sperm in the Comet assay | 2011 | Gopalan, Rajendran C.; Emerce, E.; Wright, Colin W.; Karahalil, B.; Karakaya, A.E.; Anderson, Diana | |||||||||
Low Temperature X-Ray Crystallographic Structure of the Antiplasmodial Compound 5-N-Hydroxyethanequindoline Hydrochloride 0.5CH3OH. | 2011 | Hampson, Hannah C.; Ho, Chung Y.; Palmer, R.A.; Potter, B.S.; Helliwell, M.; Wright, Colin W. | |||||||||
Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. | 2011 | Rasoanaivo, P.; Wright, Colin W.; Willcox, M.L.; Gilbert, B. | |||||||||
Cryptolepine-Induced Cell Death of Leishmania donovani Promastigotes Is Augmented by Inhibition of Autophagy. | 2011 | Sengupta, S.; Chowdhury, S.; BoseDasgupta, S.; Wright, Colin W.; Majumder, H.K. | |||||||||
A new embelin from the mangrove Aegiceras corniculatum. | 2015 | Thota, S.P.R.; Sarma, N.S.; Murthy, Y.L.N.; Kantamreddi, Venkata Siva Satya Narayana; Wright, Colin W. | |||||||||
Anticandida Agents from a Tanzanian Plant Albizia anthelmintica. | 2015 | Runyoro, D.K.B.; Joseph, C.C.; Ngassapa, O.D.; Darokar, M.P.; Srivastava, S.K.; Matee, M.I.N.; Wright, Colin W. | |||||||||
Huprines as a new family of dual acting trypanocidal–antiplasmodial agents | 2011 | Defaux, J.; Sala, M.; Formosa, X.; Galdeano, C.; Taylor, M.C.; Kelly, J.M.; Wright, Colin W.; Camps, P.; Muñoz-Torrero, D.; Alobaid, Waleed A.A. | |||||||||
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal–antiplasmodial activity. | 2015 | Sola, I.; Castellà, S.; Viayna, E.; Galdeano, C.; Taylor, M.C.; Gbedema, Stephen Y.; Pérez, B.; Clos, M.V.; Jones, D.C.; Fairlamb, A.H.; Wright, Colin W.; Kelly, J.M.; Muñoz-Torrero, D. | |||||||||
Prenylated flavanone derivatives isolated from Erythrina addisoniae are potent inducers of apoptotic cell death | 2015 | Passreiter, C.M.; Suckow-Schnitker, A-K.; Kulawik, A.; Addae-Kyereme, Jonathan A.; Wright, Colin W.; Wätjen, W. | |||||||||
Clerodane diterpenes from Polyalthia longifolia (Sonn) Thw. var. pendula: Potential antimalarial agents for drug resistant Plasmodium falciparum infection. | 2015 | Gbedema, Stephen Y.; Bayor, M.T.; Annan, K.; Wright, Colin W. | |||||||||
Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines. | 2014 | Sola, I.; Artigas, A.; Taylor, M.C.; Gbedema, Stephen Y.; Perez, B.; Clos, M.V.; Wright, Colin W.; Kelly, J.M.; Muñoz-Torrero, D. | |||||||||
Inhibition of Neuroinflammation in LPS-Activated Microglia by Cryptolepine. | 2013 | Olajide, O.A.; Bhatia, H.S.; de Oliveira, A.C.P.; Wright, Colin W.; Fiebich, B.L. | Olajide, O.A., Bhatia, H., A.C., de Oliveira, A.C.P., Wright, C.W. and Fiebich, B.L. (2013) Inhibition of neuroinflammation in LPS-activated microglia by cryptolepine. Evidence-Based Complementary and Alternative Medicine, Article ID 459723. http://dx.doi.org/10.1155/2013/459723 | ||||||||
Cajachalcone: An Antimalarial Compound from Cajanus cajan Leaf Extract | 2013 | Ajaiyeoba, E.O.; Ogbole, O.O.; Abiodun, O.O.; Ashidi, J.S.; Houghton, P.J.; Wright, Colin W. | |||||||||
Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: Possible involvement of NF-κB and p38 MAPK inhibition. | 2013 | Olajide, O.A.; Bhatia, H.S.; de Oliveira, A.C.P.; Wright, Colin W.; Fiebich, B.L. | |||||||||
Screening Indian plant species for antiplasmodial properties – ethnopharmacological compared to random selection. | 2012 | Kantamreddi, Venkata Siva Satya Narayana; Wright, Colin W. | |||||||||
Genomewide expression profiling of the cryptolepine-induced toxicity in Saccharomyces cerevisiae. | 2008 | Rojas, M.; Wright, Colin W.; Pina, B.; Portugal, J. | |||||||||
A cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations in Ghana | 2008 | Bayor, M.T.; Ayim, J.S.K.; Marston, G.; Phillips, Roger M.; Shnyder, Steven D.; Wheelhouse, Richard T.; Wright, Colin W. | |||||||||
X-ray crystallographic structure of the potent antiplasmodial compound 2,7-dibromocryptolepine acetic acid solvate. | 2008 | Potter, B.S.; Lisgarten, J.N.; Pitts, J.E.; Palmer, R.A.; Wright, Colin W. | |||||||||
Structure of the antiplasmodial compound 7,9-dinitrocryptolepine hydrochloride methanol solvate. | 2008 | Lisgarten, J.N.; Potter, B.S.; Pitts, J.E.; Palmer, R.A.; Wright, Colin W. | |||||||||
Antiplasmodial compounds from Cassia siamea stem bark extract. | 2008 | Ajaiyeoba, E.O.; Ashidi, J.S.; Okpako, Larry Commander; Houghton, P.J.; Wright, Colin W. | |||||||||
New polyhydroxy sterols from the marine sponge Callyspongia fibrosa (Ridley and Dendly). | 2010 | Rao, T.S.P.; Sarma, N.S.; Murthy, Y.L.N.; Kantamreddi, Venkata Siva Satya Narayana; Wright, Colin W.; Parameswaran, P.S. | |||||||||
Ancient Chinese methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalarial activity. | 2010 | Wright, Colin W.; Linley, Peter A.; Brun, R.; Wittlin, S.; Hsu, E. | |||||||||
Screening of Tanzanian medicinal plants against Plasmodium falciparum and human immunodeficiency virus. | 2010 | Maregesi, S.; Van Miert, S.; Pannecouque, C.; Feiz-Haddad, M.H.; Hermans, N.; Wright, Colin W.; Vlietinck, A. J.; Aspers, S.; Pieters, L. | |||||||||
Phytotherapy used in Orissa State India, for treating malaria. | 2009 | Kantamreddi, Venkata Siva Satya Narayana; Parida, S.; Kommula, S.M.; Wright, Colin W. | |||||||||
Anti-inflammatory properties of cryptolepine. | 2010 | Olajide, O.A.; Ajayi, A.A.; Wright, Colin W. | |||||||||
Evaluation of cryptolepine and huperzine derivatives as lead compounds towards new agents for the treatment of human African Trypanosomiasis. | 2009 | Oluwafemi, A.J.; Okanla, O.; Camps, P.; Muñoz-Torrero, D.; Mackey, Z.B.; Chiang, P.K.; Seville, Scott; Wright, Colin W. | |||||||||
Characterization of the cytotoxic activity of the indoloquinoline alkaloid cryptolepine in human tumour cell lines and primary cultures of tumour cells from patients. | 2009 | Laryea, D.; Isaksson, A.; Wright, Colin W.; Larsson, R.; Nygren, P. | |||||||||
Prenylated flavonoid derivatives from the bark of Erythrina addisoniae. | 2008 | Watjen, W.; Suckow-Schnitker, A-K.; Rohrig, R.; Kulawik, A.; Addae-Kyereme, Jonathan A.; Wright, Colin W.; Passreiter, C.M. | |||||||||
Enhancement of the antiplasmodial activity of quassin by transformation into a gamma-lactone. | 2003 | Wright, Colin W.; Kirby, G.C; Phillipson, J.D; Warhurst, D.C.; Lang'at-Thoruwa, C.; Watt, R.A. | |||||||||
Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action. | 2005 | Wright, Colin W.; Onyeibor, O.; Phillips, Roger M.; Shnyder, Steven D.; Croft, S.L.; Dodson, Hilary I. | |||||||||
Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents. | 2001 | Wright, Colin W.; Addae-Kyereme, Jonathan A.; Breen, Anthony G.; Brown, John E.; Cox, Marlene F.; Croft, S.L.; Gokcek, Yaman; Kendrick, H.; Phillips, Roger M.; Pollet, Pamela L. |