Dr. Richard Wheelhouse,Reader
Information about Dr. Richard Wheelhouse at the University of Bradford.
- School of Pharmacy & Medical Sciences
(Faculty of Life Sciences) - Email:
- r.t.wheelhouse@bradford.ac.uk
- Telephone:
- +44 1274 234710
Biography
2016â Honorary Professor, Faculty of Pharmacy, University of Khartoum, Sudan.2014â Reader in Medicinal Chemistry.2006â EPSRC Peer Review College, nominated by the community.
Research
Medicinal Chemistry Biophysics Anticancer Drugs Drug-Nucleic Acid Interactions Imidazotetrazines NMRUV
Research projects
Role | Date | Title/description | Funder | Award |
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PI | ||||
PI |
Professional activities
Information about education, employment and areas of particular interest for Dr. Richard Wheelhouse is as follows:
Employment
- Brown Cancer Center, University of Louisville, Kentucky, USA - Visiting Research Scientist in the year 2009 (specified as 01/04/2009)
- Bradford School of Pharmacy - Head, Division of Pharmaceutics and Pharmaceutical Chemistry in the year 2006 (specified as 01/01/2006)
- Bradford School of Pharmacy - Lecturer in the year 1998 (specified as 01/03/1998)
- The University of Texas at Austin, USA - Research Fellow in the year 1996 (specified as 01/01/1996)
- The University of Nottingham, UK - Senior Research Fellow in the year 1992 (specified as 01/01/1992)
- Aston University, Birmingham, UK - Research Associate in the year 1990 (specified as 01/01/1990)
Publications
There are 39 publications involving or that are attributed to Dr. Richard Wheelhouse. They are listed as:
- book chapter (2)
- peer reviewed journal (35)
- reviews (2)
Book Chapter
Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
---|---|---|---|---|---|---|---|---|---|---|---|
Heterocyclic N-oxidation Using Urea-Hydrogen Peroxide: a Safe, Convenient and Effective source of Hydrogen Peroxide. | 2009 | Current Issues in Organic Chemistry | Current Issues in Organic Chemistry | 63 - 71 | D. Rong, V.A. Phillips, R.T. Wheelhouse. | Heron Press | |||||
NMR and Molecular Modelling Studies on the Mechanism of Action of the Antitumour Drug Temozolomide. | 1995 | Contributions to Oncology 49: Novel Approaches in Anticancer Drug Design | Contributions to Oncology 49: Novel Approaches in Anticancer Drug Design | 40 - 49 | R.T. Wheelhouse,* B.J. Denny, M.F.G. Stevens | S. Karger |
Peer Reviewed Journal
Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
---|---|---|---|---|---|---|---|---|---|---|---|
Temozolomide: A review of its discovery, chemical properties, pre-clinical development and clinical trials | 1997 | Cancer Treatment Reviews | Newlands, E.S.;Stevens, M.F.G.;Wedge, S.R.;Wheelhouse, R.T.;Brock, C.; | 10.1016/S0305-7372(97)90019-0 | |||||||
Probing the molecular recognition of a DNA·RNA hybrid duplex | 2010 | Angewandte Chemie - International Edition | 49 | 3207 - 3210 | Wheelhouse R.;Garbett N.;Buurma N.;Chaires J. | 1433-7851 | 10.1002/anie.200907235 | ||||
Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells | 1999 | Cancer Research | 59 | 639 - 644 | Izbicka E.;Wheelhouse R.;Raymond E.;Davidson K.;Lawrence R.;Sun D.;Windle B.;Hurley L.;Von Hoff D. | 0008-5472 | |||||
Targeting of tumor cells and DNA by a chlorambucil-spermidine conjugate. | 1992 | Cancer Research | Holley JL;Mather A;Wheelhouse RT;Cullis PM;Hartley JA;Bingham JP;Cohen GM; | ||||||||
Targeting of cytotoxic agents by polyamines: Synthesis of a chlorambucil-spermidine conjugate | 1992 | Chemical Communications | 0 | Cohen, G.M.;Cullis, P.M.;Hartley, J.A.;Mather, A.;Symons, M.C.R.;Wheelhouse, R.T.; | |||||||
Motion of polyammonium ions on aqueous solutions of DNA | 1990 | Chemical Physics Letters | Besley, S.;Cullis, P.M.;Partridge, R.;Symons, M.C.R.;Wheelhouse, R.T.; | 10.1016/0009-2614(90)85415-9 | |||||||
A 15N NMR investigation of a series of benzotriazinones and related antitumour heterocycles | 2002 | Magnetic Resonance in Chemistry | Vaughan, K.;Wilman, D.E.V.;Wheelhouse, R.T.;Stevens, M.F.G.; | 10.1002/mrc.994 | |||||||
Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position | 2018 | MedChemComm | David Cousin;Marc G. Hummersone;Tracey D. Bradshaw;Jihong Zhang;Christopher J. Moody;Magdalena B. Foreiter;Helen S. Summers;William Lewis;Richard T. Wheelhouse;Malcolm F. G. Stevens; | 10.1039/c7md00554g | |||||||
Antitumour imidazotetrazines. Part 39. Synthesis of bis(imidazotetrazine)s with saturated spacer groups | 2000 | Journal of the Chemical Society, Perkin Transactions 1 | 4432 - 4438 | Arrowsmith J.;Jennings S.;Langnel D.;Wheelhouse R.;Stevens M. | 1470-4358 | 10.1039/b005652i | |||||
Antitumour imidazotetrazines. Part 36. Conversion of 5-aminoimidazole-4-carboxamide to imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-ones and imidazo[1,5-a][1,3,5]triazin-4(3H)-ones related in structure to the antitumour agents temozolomide and mitozolomide | 1998 | Journal of the Chemical Society, Perkin Transactions 1 | Wang, Y.;Wheelhouse, R.T.;Zhao, L.;Langnel, D.A.F.;Stevens, M.F.G.; | ||||||||
Antitumour imidazotetrazines. Part 31. The synthesis of isotopically labelled temozolomide and a multinuclear (1H, 13C, 15N) magnetic resonance investigation of temozolomide and mitozolomide | 1995 | Journal of the Chemical Society, Perkin Transactions 1 | 0 | R.T. Wheelhouse,* D.E.V. Wilman, W. Thomson, M.F.G. Stevens | |||||||
Polar, Functionalized Guanine-O6 Derivatives Resistant to Repair by O6-Alkylguanine-DNA Alkyltransferase: Implications for the Design of DNA-modifying Drugs. | 2009 | European Journal of Medicinal Chemistry | 41 | Wheelhouse, Richard T.; Bibby, Michael C.; Nicolaou, Anna; Pletsas, Dimitrios | |||||||
Antitumor imidazotetrazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide. | 1995 | Medicinal Chemistry | Clark AS;Deans B;Stevens MF;Tisdale MJ;Wheelhouse RT;Denny BJ;Hartley JA; | 10.1021/jm00009a010 | |||||||
Evaluation of Novel Imidazotetrazine Analogues Designed to Overcome Temozolomide Resistance and Glioblastoma Regrowth | 2015 | Molecular Cancer Therapeutics | 14 | Ramirez, Y.P.; Mladek, A.C.; Phillips, Roger M.; Gynther, M.; Rautio, J.; Ross, A.H.; Wheelhouse, Richard T.; Sakaria, J.N. | |||||||
Minor structural modifications to alchemix influence mechanism of action and pharmacological activity | 2012 | Biochemical Pharmacology | 83 | 1514 - 1522 | Abdallah Q.;Phillips R.;Johansson F.;Helleday T.;Cosentino L.;Abdel-Rahman H.;Etzad J.;Wheelhouse R.;Kiakos K.;Bingham J.;Hartley J.;Patterson L.;Pors K. | 0006-2952 | 10.1016/j.bcp.2012.02.017 | ||||
Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles | 2007 | FEBS Journal | 274 | 287 - 299 | Banks E.;Doughty S.;Toms S.;Wheelhouse R.;Nicolaou A. | 1742-464X | 10.1111/j.1742-4658.2006.05583.x | ||||
G-quadruplexes as targets for drug design | 2000 | Pharmacology and Therapeutics | Hurley, L.H.;Wheelhouse, R.T.;Sun, D.;Kerwin, S.M.;Salazar, M.;Fedoroff, O.Y.;Han, F.X.;Han, H.;Izbicka, E.;Von Hoff, D.D.; | 10.1016/S0163-7258(99)00068-6 | |||||||
Antitumour benzothiazoles. Part 4. An NMR study of the sites of protonation of 2-(4-aminophenyl)benzothiazoles | 1996 | Journal of the Chemical Society, Perkin Transactions 2 | Wheelhouse, R.T.;Shi, D.-F.;Wilman, D.E.V.;Stevens, M.F.G.; | ||||||||
NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA. | 1994 | Journal of Biochemistry | Denny BJ;Wheelhouse RT;Stevens MF;Tsang LL;Slack JA; | 10.1021/bi00197a003 | |||||||
Interactions of TMPyP4 and TMPyP2 with quadruplex DNA. Structural basis for the differential effects on telomerase inhibition | 1999 | Journal of the American Chemical Society | Han, F.X.;Wheelhouse, R.T.;Hurley, L.H.; | 10.1021/ja984153m | |||||||
Cationic porphyrins as telomerase inhibitors: The interaction of tetra- (N-methyl-4-pyridyl)porphine with quadruplex DNA [1] | 1998 | Journal of the American Chemical Society | Wheelhouse, R.T.;Sun, D.;Han, H.;Han, F.X.;Hurley, L.H.; | 10.1021/ja973792e | |||||||
Mechanism for the catalytic activation of ecteinascidin 743 and its subsequent alkylation of guanine N2 | 1998 | Journal of the American Chemical Society | Moore II, B.M.;Seaman, F.C.;Wheelhouse, R.T.;Hurley, L.H.; | 10.1021/ja974109r | |||||||
A novel, high-yielding synthesis of meso-substituted porphyrins via the direct arylation of porphine | 2002 | Tetrahedron Letters | 43 | 9341 - 9342 | Shi D.;Wheelhouse R. | 0040-4039 | 10.1016/S0040-4039(02)02339-0 | ||||
A safe, convenient and efficient method for the preparation of heterocyclic N-oxides using urea·hydrogen peroxide | 2008 | Tetrahedron Letters | 49 | 6933 - 6935 | Rong D.;Phillips V.;Rubio R.;Ángeles Castro M.;Wheelhouse R. | 0040-4039 | 10.1016/j.tetlet.2008.09.124 | ||||
In-vitro cytotoxic activities of the major bromophenols of the red alga Polysiphonia lanosa and some novel synthetic isomers | 2004 | Journal of Natural Products | 67 | 1445 - 1449 | Shoeib N.;Bibby M.;Blunden G.;Linley P.;Swaine D.;Wheelhouse R.;Wright C. | 0163-3864 | 10.1021/np0305268 | ||||
A cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations used in Ghana | 2008 | Natural product communications | Bayor, M.T.;Ayim, J.S.K.;Marston, G.;Phillips, R.M.;Shnyder, S.D.;Wheelhouse, R.T.;Wright, C.W.; | ||||||||
Design, synthesis, and evaluation of novel biarylpyrimidines: A new class of ligand for unusual nucleic acid structures | 2006 | Journal of Medicinal Chemistry | 49 | 5187 - 5198 | Wheelhouse R.;Jennings S.;Phillips V.;Pletsas D.;Murphy P.;Garbett N.;Chaires J.;Jenkins T. | 0022-2623 | 10.1021/jm060315a | ||||
Quadruplex-interactive agents as telomerase inhibitors: Synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase | 2001 | Journal of Medicinal Chemistry | 44 | 4509 - 4523 | Shi D.;Wheelhouse R.;Sun D.;Hurley L. | 0022-2623 | 10.1021/jm010246u | ||||
Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA- methyltransferase, DNA mismatch repair, and p53 | 2013 | Journal of Medicinal Chemistry | 56 | Pletsas, D.;Garelnabi, E.A.E.;Li, L.;Phillips, R.M.;Wheelhouse, R.T.; | 10.1021/jm401121k | ||||||
The medicinal chemistry of imidazotetrazine prodrugs | 2014 | Pharmaceuticals | Moody, C.L.;Wheelhouse, R.T.; | 10.3390/ph7070797 | |||||||
Decomposition of the antitumour drug temozolomide in deuteriated phosphate buffer: Methyl group transfer is accompanied by deuterium exchange | 1993 | Journal of the Chemical Society - Series Chemical Communications | Wheelhouse, R.T.;Stevens, M.F.G.; | ||||||||
Stabilization of a bimolecular triplex by 3'-S-phosphorothiolate modifications: An NMR and UV thermal melting investigation | 2015 | CHEMISTRY - A EUROPEAN JOURNAL | 21 | Evans, K.;Bhamra, I.;Wheelhouse, R.T.;Arnold, J.R.P.;Cosstick, R.;Fisher, J.; | 10.1002/chem.201500369 | ||||||
Telomere-interactive agents affect proliferation rates and induce chromosomal destabilization in sea urchin embryos | 1999 | Anti-Cancer Drug Design | 14 | 355 - 365 | Izbicka E.;Nishioka D.;Marcell V.;Raymond E.;Davidson K.;Lawrence R.;Wheelhouse R.;Hurley L.;Wu R.;Von Hoff D. | 0266-9536 | |||||
Structural studies on bioactive compounds. Part 27. Chemistry of the immunomodulatory agent bropirimine. | 1995 | Anti-Cancer Drug Design | 10 | Stevens MF;Baig GU;Gate EN;Wheelhouse RT; | |||||||
Biarylpyrimidines: a new class of ligand for high-order DNA recognition. | 2003 | CHEMICAL COMMUNICATIONS (PRINT) | 0 | Murphy PM;Phillips VA;Jennings SA;Garbett NC;Chaires JB;Jenkins TC;Wheelhouse RT; | 10.1039/b301554h |
Reviews
Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
---|---|---|---|---|---|---|---|---|---|---|---|
Glioblastoma multiforme therapy and mechanisms of resistance | 2013 | Pharmaceuticals | 6 | 1475 - 1506 | Ramirez Y.;Weatherbee J.;Wheelhouse R.;Ross A. | 1424-8247 | 10.3390/ph6121475 | ||||
The medicinal chemistry of imidazotetrazine prodrugs | 2014 | Pharmaceuticals | 7 | 797 - 838 | Moody C.;Wheelhouse R. | 1424-8247 | 10.3390/ph7070797 |