Dr. Huw Simon Jones,Lecturer in Drug Metabolism and Medical
Information about Dr. Huw Simon Jones at the University of Bradford.
- School of Pharmacy & Medical Sciences
(Faculty of Life Sciences) - Email:
- h.s.jones@bradford.ac.uk
- Telephone:
- +44 1274 234217
Biography
Huw Jones studied medical biochemistry, followed by a Masters in molecular mechanistic toxicology, at the University of Birmingham. Following his PhD studies (investigating how zebrafish larvae metabolise drugs, University of Birmingham), he undertook post-doctoral positions at the University of Sheffield and the Hull York Medical School (University of Hull). Having spent 4 years as a lecturer in biochemistry at the University of Hull, he is now a Lecturer in drug metabolism and medical biochemistry at the School of Pharmacy and Medical Sciences, and leads the drug metabolism and pharmacokinetics (DMPK) team in the Institute for Cancer Therapeutics.
Research
Dr Jones' research interests are focused on: - The pharmacology of natural products (particularly dietary polyphenols) in health and disease states, with a particular focus on the modulation of oxidative stress and RONS signalling in diseases associated with ageing. - The pharmacokinetics of drugs. - Novel methods for the synthesis of drug metabolites and modelling of drug metabolism.- Development of more robust methods for measuring RONS species and their reaction products with cellular macromolecules. A key cornerstone of his research is using physiologically-relevant test compound exposures in in vitro systems. This involves ensuring that (i) the amount of test compound cells are exposed to is comparable to concentrations detected in vivo, (ii) that the duration of exposure is similar to the time compounds are known to persist in vivo, and (iii) the test compound is in a relevant form (i.e. in a form that has been detected in vivo). In order to adhere to these principles as much as possible, Dr Jones is interested in the pharmacokinetics of test compounds (at both a cellular and whole organism level), and methods that allow you to predict or generate compounds and data to inform in vitro testing approaches. He applies this approach to understanding how natural products (especially polyphenols) can act as drugs.
Teaching
Details on teaching interests, highlights and modules are available for Dr. Huw Simon Jones as follows:
Teaching interests
Dr Jones teaches on a wide range of modules across the Clinical Sciences degree programme, especially on subjects related to biochemistry. He also contributes to the delivery of the MSc and MRes programmes within the Institute of Cancer Therapeutics.
Publications
There are 14 publications involving or that are attributed to Dr. Huw Simon Jones. They are listed as:
- book chapter (1)
- non-peer reviewed journal (1)
- peer reviewed journal (12)
Book Chapter
Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
---|---|---|---|---|---|---|---|---|---|---|---|
Behaviour of Dietary Oligosaccharides in the Human Gastrointestinal Tract | 2014 | Oligosaccharides: Food Sources, Biological Roles and Health Implications | Oligosaccharides: Food Sources, Biological Roles and Health Implications | Fraser L. Courts, Liz K. Wells, Stephanie K. Allen, Huw S. Jones | 978-1-62948-328-3 | Nova Science Publishers, Inc. |
Non-peer reviewed Journal
Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
---|---|---|---|---|---|---|---|---|---|---|---|
he Impact of High-Intensity Interval Exercise Including Acceleration/Deceleration Patterns on Redox Status of Healthy Male Adults | 2024 | Applied Sciences | Chalari, E.;Jones, H.S.;Hadjicharalambous, M.;Fogarty, M.C. | https://doi.org/10.3390/app14062655 |
Peer Reviewed Journal
Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
---|---|---|---|---|---|---|---|---|---|---|---|
Immobilised-enzyme microreactors for the identification and synthesis of conjugated drug metabolites | 2023 | RSC Advances | 13 | Bradley Doyle, Leigh Madden, Nicole Pamme and Huw Simon Jones | |||||||
Physiologically-obtainable polyphenol exposures modulate reactive oxygen and nitrogen species signaling in the C2C12 model of skeletal muscle ageing. | 2023 | European Journal of Pharmacology | 941 | Hayes N;Fogarty M;Sadofsky L;Jones HS; | 1879-0712 | 10.1016/j.ejphar.2023.175511 | |||||
Co-Loading of Black Phosphorus Nanoflakes and Doxorubicin in Lysolipid Temperature-Sensitive Liposomes for Combination Therapy in Prostate Cancer. | 2023 | International Journal of Molecular Sciences | 25 | Das C;Martín C;Habermann S;Walker HR;Iqbal J;Elies J;Jones HS;Reina G;Ruiz A; | 1422-0067 | 10.3390/ijms25010115 | |||||
Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: A viable workflow and a cautionary tale. | 2019 | Biochemical Pharmacology | Jones HS;Papageorgiou M;Gordon A;Ehtesham ;Javed Z;Wells LK;Greetham S;Doyle B;Hayes N;Rigby A;Atkin SL;Courts FL;Sathyapalan T; | 1873-2968 | 10.1016/j.bcp.2019.113754 | ||||||
Effectiveness of Short-Term Heat Acclimation on Intermittent Sprint Performance With Moderately Trained Females Controlling for Menstrual Cycle Phase. | 2019 | Frontiers in Physiology | 10 | Garrett AT;Dodd E;Biddlecombe V;Gleadall-Siddall D;Burke R;Shaw J;Bray J;Jones H;Abt G;Gritt J; | 1664-042X | 10.3389/fphys.2019.01458 | |||||
The Effects of Acute Interval Exercise and Strawberry Intake on Postprandial Lipemia. | 2017 | Medicine and Science in Sports and Exercise | 49 | O'Doherty AF;Jones HS;Sathyapalan T;Ingle L;Carroll S; | 1530-0315 | 10.1249/MSS.0000000000001341 | |||||
The dietary flavonol quercetin ameliorates angiotensin II-induced redox signaling imbalance in a human unbilical vein endothelial cell model of endothelial dysfunction via ablation of p47phox expression | 2016 | Molecular Nutrition and Food Research | 60 | 787 - 797 | Jones HS, Gordon A, Magwenzi SG, Naseem A, Atkin SL, Courts FL | 1613-4133 | Wiley | 10.1002/mnfr.201500751 | |||
Pilot Investigation of a Virtual Gastric Band Hypnotherapy Intervention. | 2016 | International Journal of Clinical and Experimental Hypnosis | 64 | Greetham S;Goodwin S;Wells L;Whitham C;Jones H;Rigby A;Sathyapalan T;Reid M;Atkin S; | 1744-5183 | 10.1080/00207144.2016.1209037 | |||||
Oxidised LDL activates blood platelets through CD36/NOX2-mediated inhibition of the cGMP/protein kinase G signalling cascade | 2015 | Blood | 125 | Magwenzi S; Woodward C;Wraith KS; Aburima A; Raslan Z; Jones H, McNeil C; Wheatcroft S; Yuldasheva N; Febbriao M; Kearney M; Naseem K | 1528-0020 | 10.1182/blood-2014-05-574491 | |||||
Metabolism of ibuprofen in zebrafish larvae. | 2012 | Xenobiotica | 42 | Jones HS;Trollope HT;Hutchinson TH;Panter GH;Chipman JK; | 1366-5928 | 10.3109/00498254.2012.684410 | |||||
Interference with xenobiotic metabolic activity by the commonly used vehicle solvents dimethylsulfoxide and methanol in zebrafish (Danio rerio) larvae but not Daphnia magna. | 2012 | Chemosphere | 88 | David RM;Jones HS;Panter GH;Winter MJ;Hutchinson TH;Kevin Chipman J; | 1879-1298 | 10.1016/j.chemosphere.2012.03.018 | |||||
Oxidative and conjugative xenobiotic metabolism in zebrafish larvae in vivo. | 2010 | Zebrafish | 7 | Jones HS;Panter GH;Hutchinson TH;Chipman JK; | 1557-8542 | 10.1089/zeb.2009.0630 |